The prevalence and related factors of pre?diabetes and diabetes among overweight and obese children in Urban schools

Objective: This study aimed to determine the prevalence of pre?diabetes and diabetes among overweight and obese children in urban schools and factors associated with them, in Batticaloa District, Sri Lanka. Methods: A school based cross?sectional descriptive study was conducted to collect data on socio-demographic information, eating habits and physical activities, using a validated, pre-tested questionnaire. In addition, anthropometric measurements and glycosylated haemoglobin (HbA1c) test were performed. Multivariate logistic regression analyze was performed to identify the factors associated with glycemic status by using SPSS v23. Results: Out of the 269 children recruited, 59% were obese. Prevalence of pre?diabetes (HbA1c 5.7%�4%) and diabetes (HbA1c ? 6.5%) were 20.1% (95% CI 15.5%�.4%) and 3.3% (95% CI 1.5%�3%) respectively. Multivariate regression shows that having a BMI of ? 27.5Kg/m2 (AOR=2.69), male gender (AOR=2.71) and ethnicity (AOR = 2.58) were found to be significant factors for higher HbA1c (?5.7%). Conclusions: Prevalence of prediabetes and diabetes among overweight and obese school children was high and mainly associated with body weight which is a modifiable risk factor. Lifestyle modifications focusing on weight reduction among overweight and obese school children especially boys, need to be carried out.

Effects of 70% isopropyl alcohol wipes and bleachbased wipes in disinfecting nurses' mobile phone: a quasi-experimental approach / The Health Sciences Journal

INTRODUCTION@#Concerns have been increased about the use of mobile phones in hospitals as they may be vehicles for the transmission of hospital-acquired infections. This study aimed to compare the effectiveness of 70% isopropyl alcohol wipes with bleach-based wipes in decreasing bacterial colony counts of mobile phones of staff nurses.@*METHODS@#Mobile phones of staff nurses in the UERM Hospital were assigned to be disinfected with 70% isopropyl alcohol wipes or bleach-based wipes. Mobile phones were swabbed using standard techniques before and after disinfection with 70% isopropyl alcohol wipes or bleach-based wipes. Post-disinfection colony counts were compared with baseline counts in each group and compared between the two test groups.@*RESULTS@#There was a significant decrease in the post-disinfection mean colony count compared with the mean baseline colony count in both the 70% isopropyl alcohol wipes (p < 0.001) and bleach-based wipes (p = 0.002) groups. The decrease in the 70% isopropyl alcohol wipes group was bigger (121,635 vs 85,769 CFU/mL). The mean post-disinfection colony count of the 70% isopropyl alcohol wipes was significantly lower (p = 0.007) than the other group.@*CONCLUSION@#Both 70% isopropyl alcohol wipes and bleach-based wipes are effective in decreasing bacterial colony counts of mobile phones of staff nurses. The alcohol wipes resulted in a greater decrease in colony count compared with the bleach wipes.

Sequence analysis of the VSXI and SODl genes in families with Keratoconus and a review of the literature

Objective: Keratoconus [KC] is a non-inflammatory disorder of the cornea in which the cornea becomes thin and conical, inducing myopia and irregular astigmatism and resulting in mild to marked impairment of vision. The present study was designed to screen two candidate KC genes to identify pathogenic sequence variants responsible for KC in Saudi families

Methods: Peripheral blood samples from members of five Saudi families with KC from the Northern region were collected. Genomic DNA was isolated, and bidirectional sequencing was performed of all coding exons of VSX1 and SOD1 genes using Sanger sequencing

Results: All five of the KC families showed a pattern of autosomal recessive inheritance. Phenotyping of these families was performed by a senior ophthalmologist. Sequence analysis of the VSX1 and SOD1 genes failed to reveal any pathogenic sequence variant that could account for KC in the affected individuals

Conclusion: Our failure to detect sequence variants in two of the known KC associated genes triggers an interest in other known KC candidate genes, including miR-184, DOCK9, IL1RN and SLC4A11. Future genotyping with dense SNP arrays followed by exome sequencing in these families will be a useful approach to identify the gene[s] underlying KC in this Saudi cohort, which may be different from those reported elsewhere.

Efecto del zinc aminoquelado y el sulfato de zinc en la incidencia de la infección respiratoria y la diarrea en niños preescolares de centros infantiles / Effect of zinc amino acid chelate and zinc sulfate in the incidence of respiratory infection and diarrhea among preschool children in child daycare centers

Introducción. El déficit de zinc es común en niños de poblaciones en desarrollo. La deficiencia de zinc altera el sistema inmunológico y la resistencia a las infecciones. Objetivo. Evaluar el efecto de dos compuestos de zinc en la prevención de la infección respiratoria y la diarrea agudas. Materiales y métodos. Se llevó a cabo un ensayo comunitario triple ciego en 301 niños entre dos y cinco años de edad de centros infantiles de Medellín. Fueron seis conglomerados distribuidos aleatoriamente en tres grupos de intervención que recibieron zinc aminoquelado, sulfato de zinc y placebo durante cinco días de la semana a lo largo de 16 semanas. Se evaluaron diariamente los síntomas de infección respiratoria, diarrea aguda y efectos secundarios. Resultados. La incidencia de la infección respiratoria fue menor con el zinc aminoquelado (1,42 por 1.000 días-niño) comparado con el sulfato de zinc (1,57 por 1.000 días-niño) (RR=0,90, IC 95% : 0,382 a 2,153 , p=0,999) y con el placebo (3,3 por 1.000 días-niño) ( RR=0,43, IC 95% : 0,196 a 0,950 , p=0,049). La incidencia de diarrea aguda con el zinc aminoquelado (0,15 por 1.000 días-niño) fue menor que con el sulfato de zinc (1,18 0,78 por 1.000 días-niño) (RR=0,20, IC 95% : 0,0043 a 1,662, p=0,361) y que la del grupo placebo (0,49 por 1.000 días-niño) (RR=0,32, IC 95% : 0,006 a 3,990 , p=0,346). Conclusiones. El zinc aminoquelado tuvo mejor efecto en la disminución de la incidencia de la infección respiratoria y la diarrea agudas en niños preescolares comparado con los otros grupos de estudio.

Introduction: Zinc deficiency is common in children among populations in developing areas. Zinc deficiency alters the immune system and the resistance to infections. Objective: To evaluate the effect of two zinc compounds in the prevention of acute respiratory infection and acute diarrhea. Materials and methods: Randomized triple-blind community trial with 301 children between 2-5 years of age from six child daycare centers in Medellin, Colombia. Children were distributed in three groups receiving zinc amino acid chelate, zinc sulfate and placebo five days a week for 16 weeks. Daily symptoms of respiratory infection, acute diarrhea and side effects were evaluated. Results: The incidence of respiratory infection was lower with zinc amino acid chelate (1.42 per 1,000 child-days) compared with placebo (3.3 per 1,000 child-days) (RR=0.43, 95% CI: 0.196 to 0.950, p=0.049) and with zinc sulfate (1.57 per 1,000 child-days) (RR=0.90, 95% CI 0.382 to 2.153, p=0.999). The incidence of acute diarrhea with zinc amino acid chelate (0.15 per 1,000 child-days) was lower than with placebo (0.49 per 1,000 child-days) (RR=0.32, 95% CI 0.006 to 3.990, p=0.346) and with zinc sulfate (0.78 per 1,000 child-days) (RR=0.20, 95% CI: 0.0043 to 1.662, p=0.361). Conclusions: Zinc amino acid chelate had a better effect in reducing the incidence of acute respiratory infection and acute diarrhea in preschool children when compared with the other groups.